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Doktorandenstelle in Zellbiologie und Physiologie (Bochum) PDF Print E-mail
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Thursday, 14 October 2010 00:04

Eine Doktorandenstelle ist verfügbar im Projekt “Herstellung einer Maus mit knock-out des sarkomeren M-Linien Proteins Myomesin in Herz und Skelettmuskel“
(funded by a FoRUM grant from the Ruhr-University Medical Center)
Projekt Beschreibung: Myomesin ist ein Strukturprotein in der M-Bande des Sarkomers von Herz- und Skelettmuskel. Myomesin verbindet die dicken Myosin Filamente und die elastischen Titin Filamente miteinander und reguliert ihre Interaktion. Daneben wird Myomesin als Sensor für mechanischen Stress in der Mitte des Sarkomers und als wichtiges Molekül phosphorylierungsabhängiger Signaltransduktion im quergestreiften Muskel betrachtet.
Die physiologische Rolle des Myomesins in vivo ist jedoch völlig unbekannt und soll analysiert werden. Wir haben einen murinen ES Zellklon identifiziert, aus dem eine Myomesin knock-out Maus erzeugt werden soll. Mit Hilfe dieser Tiere wollen wir analysieren, inwieweit die Entwicklung der Maus durch das Fehlen des Myomesin Gens beeinflusst wird. Das übergeordnete Ziel unserer Studien ist es, im Mausmodell die Funktion von Myomesin als Mechanosensor, als Bestandteil von Signalketten und als Organisator der M-Bande des sarkomeren Muskels zu verstehen. References: Obermann et al. Mol Biol Cell 9: 829-840 (1998); Obermann et al. EMBO J 16: 211-220 (1997); Obermann et al. J Cell Biol 134: 1441-1453 (1996).

Your profile: Master degree or Diploma in Biochemistry, Cell Biology, Molecular Biology or Physiology with expertise in breeding and genotyping of mouse models.

To apply, candidates should provide a letter of motivation and statement of research interests, their CV, 2 letters of recommendation and a copy of their degree to:
PD Dr. Wolfgang M. J. Obermann, Institute for Physiology, Building MA 3/157
Ruhr-University Bochum, Universitätsstr. 150, 44801 Bochum, Germany
This e-mail address is being protected from spambots. You need JavaScript enabled to view it


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Von:

PD Dr. Wolfgang Obermann
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Ruhr-Universität Bochum
Bochum

Ansprechpartner: Wolfgang Obermann, This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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*http://jobs.uni-hd.de
Tags: PhD Biological Sciences Full Funding Germany Wordwide

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